{"cited_by_count":2446125,"description":"This cluster of papers focuses on the recognition and signaling pathways of innate immunity, particularly through Toll-like receptors and pattern recognition receptors. It explores the role of these receptors in pathogen recognition, inflammation, antiviral responses, and the regulation of adaptive immunity. The cluster also delves into the molecular mechanisms and mediators involved in innate immune responses.","display_name":"Immune Response and Inflammation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10371","wikipedia":"https://en.wikipedia.org/wiki/Innate_immune_system"},"field_id":"24","id":"T10371","keywords":[{"display_name":"TLR4","id":"tlr4","score":0.2195,"url":"https://openalex.org/keywords/tlr4"},{"display_name":"Toll-like receptors","id":"toll-like-receptors","score":0.3377,"url":"https://openalex.org/keywords/toll-like-receptors"},{"display_name":"TLR2","id":"tlr2","score":0.2673,"url":"https://openalex.org/keywords/tlr2"},{"display_name":"pattern recognition receptors","id":"pattern-recognition-receptors","score":0.3001,"url":"https://openalex.org/keywords/pattern-recognition-receptors"},{"display_name":"MyD88","id":"myd88","score":0.2769,"url":"https://openalex.org/keywords/myd88"},{"display_name":"Toll-like receptor signaling","id":"toll-like-receptor-signaling","score":0.2635,"url":"https://openalex.org/keywords/toll-like-receptor-signaling"},{"display_name":"TLR9","id":"tlr9","score":0.2975,"url":"https://openalex.org/keywords/tlr9"},{"display_name":"TLR3","id":"tlr3","score":0.2866,"url":"https://openalex.org/keywords/tlr3"},{"display_name":"pathogen-associated molecular patterns","id":"pathogen-associated-molecular-patterns","score":0.269,"url":"https://openalex.org/keywords/pathogen-associated-molecular-patterns"},{"display_name":"TLR7","id":"tlr7","score":0.2825,"url":"https://openalex.org/keywords/tlr7"},{"display_name":"NOD2","id":"nod2","score":0.2563,"url":"https://openalex.org/keywords/nod2"},{"display_name":"lipid A","id":"lipid-a","score":0.2674,"url":"https://openalex.org/keywords/lipid-a"},{"display_name":"endotoxin tolerance","id":"endotoxin-tolerance","score":0.5228,"url":"https://openalex.org/keywords/endotoxin-tolerance"},{"display_name":"TLR5","id":"tlr5","score":0.3652,"url":"https://openalex.org/keywords/tlr5"},{"display_name":"TLR4 signaling","id":"tlr4-signaling","score":0.2479,"url":"https://openalex.org/keywords/tlr4-signaling"},{"display_name":"MD-2","id":"md-2","score":0.5457,"url":"https://openalex.org/keywords/md-2"},{"display_name":"TRIF","id":"trif","score":0.4177,"url":"https://openalex.org/keywords/trif"},{"display_name":"NOD-like receptors","id":"nod-like-receptors","score":0.2915,"url":"https://openalex.org/keywords/nod-like-receptors"},{"display_name":"TLR8","id":"tlr8","score":0.3558,"url":"https://openalex.org/keywords/tlr8"},{"display_name":"pathogen recognition","id":"pathogen-recognition","score":0.2817,"url":"https://openalex.org/keywords/pathogen-recognition"},{"display_name":"NOD1","id":"nod1","score":0.389,"url":"https://openalex.org/keywords/nod1"},{"display_name":"muramyl dipeptide","id":"muramyl-dipeptide","score":0.2702,"url":"https://openalex.org/keywords/muramyl-dipeptide"},{"display_name":"TLR agonists","id":"toll-like-receptor-agonists","score":0.2054,"url":"https://openalex.org/keywords/toll-like-receptor-agonists"},{"display_name":"TIR domain","id":"tir-domain","score":0.5069,"url":"https://openalex.org/keywords/tir-domain"},{"display_name":"Dectin-1","id":"dectin-1","score":0.2078,"url":"https://openalex.org/keywords/dectin-1"}],"legacy_keywords":["Toll-like Receptors","Pattern Recognition Receptors","Inflammation","Innate Antiviral Responses","Cytokine-Mediated Link","Pathogen Recognition","NOD-Like Receptors","Endotoxin Hyporesponsiveness","DAMPs","Adaptive Immunity Regulation"],"openalex_id":"https://openalex.org/T10371","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T10371","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10371","works_count":78384,"label":"Immune Response and Inflammation","provider":"openalex","revision":"0edca0c3aa58a164","taxonomy_revision":"f050b5d4780b1289","title":"Immune Response and Inflammation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36239922650292429","address_version":"morton4x16-v1","coordinates":[1,24,2403,10371],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}