{"cited_by_count":2378136,"description":"This cluster of papers explores the complex landscape of functional bowel disorders, with a focus on conditions such as irritable bowel syndrome, constipation, and gastroparesis. It delves into the role of microbiota, enteric nervous system, and intestinal permeability in these disorders, as well as the potential therapeutic impact of probiotics and serotonin signaling. Additionally, the cluster addresses the prevalence, epidemiology, and global burden of functional gastrointestinal disorders.","display_name":"Gastrointestinal motility and disorders","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10365","wikipedia":"https://en.wikipedia.org/wiki/Functional_bowel_disorder"},"field_id":"27","id":"T10365","keywords":[{"display_name":"irritable bowel syndrome","id":"irritable-bowel-syndrome","score":0.6387,"url":"https://openalex.org/keywords/irritable-bowel-syndrome"},{"display_name":"constipation","id":"constipation","score":0.3164,"url":"https://openalex.org/keywords/constipation"},{"display_name":"gastrointestinal motility","id":"gastrointestinal-motility","score":0.5609,"url":"https://openalex.org/keywords/gastrointestinal-motility"},{"display_name":"gastric emptying","id":"gastric-emptying","score":0.4899,"url":"https://openalex.org/keywords/gastric-emptying"},{"display_name":"functional dyspepsia","id":"functional-dyspepsia","score":0.6351,"url":"https://openalex.org/keywords/functional-dyspepsia"},{"display_name":"functional gastrointestinal disorders","id":"functional-gastrointestinal-disorders","score":0.7319,"url":"https://openalex.org/keywords/functional-gastrointestinal-disorders"},{"display_name":"gastric motility","id":"gastric-motility","score":0.6495,"url":"https://openalex.org/keywords/gastric-motility"},{"display_name":"intestinal motility","id":"intestinal-motility","score":0.471,"url":"https://openalex.org/keywords/intestinal-motility"},{"display_name":"enteric nervous system","id":"enteric-nervous-system","score":0.405,"url":"https://openalex.org/keywords/enteric-nervous-system"},{"display_name":"chronic constipation","id":"chronic-constipation","score":0.5959,"url":"https://openalex.org/keywords/chronic-constipation"},{"display_name":"colonic motility","id":"colonic-motility","score":0.6862,"url":"https://openalex.org/keywords/colonic-motility"},{"display_name":"functional constipation","id":"functional-constipation","score":0.8134,"url":"https://openalex.org/keywords/functional-constipation"},{"display_name":"gastric secretion","id":"gastric-secretion","score":0.2753,"url":"https://openalex.org/keywords/gastric-secretion"},{"display_name":"gastroparesis","id":"gastroparesis","score":0.5896,"url":"https://openalex.org/keywords/gastroparesis"},{"display_name":"visceral hypersensitivity","id":"visceral-hypersensitivity","score":0.6278,"url":"https://openalex.org/keywords/visceral-hypersensitivity"},{"display_name":"bloating","id":"bloating","score":0.5186,"url":"https://openalex.org/keywords/bloating"},{"display_name":"irritable bowel syndrome with constipation","id":"irritable-bowel-syndrome-with-constipation","score":0.8811,"url":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation"},{"display_name":"pediatric constipation","id":"pediatric-constipation","score":0.7933,"url":"https://openalex.org/keywords/pediatric-constipation"},{"display_name":"laxatives","id":"laxatives","score":0.3468,"url":"https://openalex.org/keywords/laxatives"},{"display_name":"delayed gastric emptying","id":"delayed-gastric-emptying","score":0.4273,"url":"https://openalex.org/keywords/delayed-gastric-emptying"},{"display_name":"stool frequency","id":"stool-frequency","score":0.4531,"url":"https://openalex.org/keywords/stool-frequency"},{"display_name":"prokinetic agents","id":"prokinetic-agents","score":0.4571,"url":"https://openalex.org/keywords/prokinetic-agents"},{"display_name":"diarrhea-predominant irritable bowel syndrome","id":"diarrhea-predominant-irritable-bowel-syndrome","score":0.813,"url":"https://openalex.org/keywords/diarrhea-predominant-irritable-bowel-syndrome"},{"display_name":"gastrointestinal motility disorders","id":"gastrointestinal-motility-disorders","score":0.5817,"url":"https://openalex.org/keywords/gastrointestinal-motility-disorders"},{"display_name":"interstitial cells of Cajal","id":"interstitial-cells-of-cajal","score":0.5738,"url":"https://openalex.org/keywords/interstitial-cells-of-cajal"}],"legacy_keywords":["Irritable Bowel Syndrome","Gastrointestinal Disorders","Microbiota","Enteric Nervous System","Constipation","Probiotics","Intestinal Permeability","Gastroparesis","Serotonin Signaling","Inflammation"],"openalex_id":"https://openalex.org/T10365","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2715","url":"/topics/T10365","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10365","works_count":186858,"label":"Gastrointestinal motility and disorders","provider":"openalex","revision":"571804ff1fffec1b","taxonomy_revision":"f050b5d4780b1289","title":"Gastrointestinal motility and disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240179346729326","address_version":"morton4x16-v1","coordinates":[4,27,2715,10365],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}