{"cited_by_count":2826455,"description":"This cluster of papers focuses on the molecular, genetic, and physiological aspects of mammalian circadian rhythms, including the role of the circadian clock, melatonin, retinal ganglion cells, metabolism, peripheral clocks, phototransduction, gene expression, oxidative stress, and the health effects of sleep disruption.","display_name":"Circadian rhythm and melatonin","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10342","wikipedia":"https://en.wikipedia.org/wiki/Circadian_rhythm"},"field_id":"28","id":"T10342","keywords":[{"display_name":"circadian rhythm","id":"circadian-rhythm","score":0.4435,"url":"https://openalex.org/keywords/circadian-rhythm"},{"display_name":"melatonin","id":"melatonin","score":0.4123,"url":"https://openalex.org/keywords/melatonin"},{"display_name":"circadian clock","id":"circadian-clock","score":0.6799,"url":"https://openalex.org/keywords/circadian-clock"},{"display_name":"pineal gland","id":"pineal-gland","score":0.6313,"url":"https://openalex.org/keywords/pineal-gland"},{"display_name":"suprachiasmatic nucleus","id":"suprachiasmatic-nucleus","score":0.7572,"url":"https://openalex.org/keywords/suprachiasmatic-nucleus"},{"display_name":"clock genes","id":"clock-genes","score":0.6976,"url":"https://openalex.org/keywords/clock-genes"},{"display_name":"light-dark cycle","id":"light-dark-cycle","score":0.4851,"url":"https://openalex.org/keywords/light-dark-cycle"},{"display_name":"chronobiology","id":"chronobiology","score":0.5402,"url":"https://openalex.org/keywords/chronobiology"},{"display_name":"circadian rhythm disruption","id":"circadian-rhythm-disruption","score":0.4206,"url":"https://openalex.org/keywords/circadian-rhythm-disruption"},{"display_name":"biological rhythms","id":"biological-rhythms","score":0.4662,"url":"https://openalex.org/keywords/biological-rhythms"},{"display_name":"biological clock","id":"biological-clock","score":0.6415,"url":"https://openalex.org/keywords/biological-clock"},{"display_name":"Bmal1","id":"bmal1","score":0.6638,"url":"https://openalex.org/keywords/bmal1"},{"display_name":"sleep-wake cycle","id":"sleep-wake-cycle","score":0.2585,"url":"https://openalex.org/keywords/sleep-wake-cycle"},{"display_name":"light exposure","id":"light-exposure","score":0.2084,"url":"https://openalex.org/keywords/light-exposure"},{"display_name":"melatonin receptors","id":"melatonin-receptors","score":0.7083,"url":"https://openalex.org/keywords/melatonin-receptors"},{"display_name":"melatonin synthesis","id":"melatonin-synthesis","score":0.7394,"url":"https://openalex.org/keywords/melatonin-synthesis"},{"display_name":"light entrainment","id":"photic-entrainment","score":0.8761,"url":"https://openalex.org/keywords/photic-entrainment"},{"display_name":"constant darkness","id":"constant-darkness","score":0.7375,"url":"https://openalex.org/keywords/constant-darkness"},{"display_name":"chronotype","id":"chronotype","score":0.2205,"url":"https://openalex.org/keywords/chronotype"},{"display_name":"Per2","id":"per2","score":0.7346,"url":"https://openalex.org/keywords/per2"},{"display_name":"chronotherapy","id":"chronotherapy","score":0.4517,"url":"https://openalex.org/keywords/chronotherapy"},{"display_name":"jet lag","id":"jet-lag","score":0.5283,"url":"https://openalex.org/keywords/jet-lag"},{"display_name":"circadian pacemaker","id":"circadian-pacemaker","score":0.8477,"url":"https://openalex.org/keywords/circadian-pacemaker"},{"display_name":"circadian entrainment","id":"circadian-entrainment","score":0.7726,"url":"https://openalex.org/keywords/circadian-entrainment"},{"display_name":"constant light","id":"constant-light","score":0.4283,"url":"https://openalex.org/keywords/constant-light"}],"legacy_keywords":["Circadian Clock","Melatonin","Retinal Ganglion Cells","Metabolism","Peripheral Clocks","Phototransduction","Gene Expression","Oxidative Stress","Sleep Disruption","Health Effects"],"openalex_id":"https://openalex.org/T10342","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2807","url":"/topics/T10342","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10342","works_count":123016,"label":"Circadian rhythm and melatonin","provider":"openalex","revision":"adf47d852df1ebed","taxonomy_revision":"f050b5d4780b1289","title":"Circadian rhythm and melatonin","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240179417460421","address_version":"morton4x16-v1","coordinates":[1,28,2807,10342],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}