{"cited_by_count":2513143,"description":"This cluster of papers focuses on the role of cancer stem cells, epithelial-mesenchymal transition, and the tumor microenvironment in tumor metastasis, drug resistance, and cell plasticity. It explores the identification, regulation, and behavior of cancer stem cells, as well as their interactions with the microenvironment and implications for metastatic colonization. Additionally, it delves into the use of organoid models to study cancer stem cells and tumor progression.","display_name":"Cancer Cells and Metastasis","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10336","wikipedia":"https://en.wikipedia.org/wiki/Cancer_stem_cell"},"field_id":"27","id":"T10336","keywords":[{"display_name":"cancer stem cells","id":"cancer-stem-cells","score":0.3741,"url":"https://openalex.org/keywords/cancer-stem-cells"},{"display_name":"CD133","id":"cd133","score":0.3073,"url":"https://openalex.org/keywords/cd133"},{"display_name":"breast cancer stem cells","id":"breast-cancer-stem-cells","score":0.5064,"url":"https://openalex.org/keywords/breast-cancer-stem-cells"},{"display_name":"cancer stemness","id":"cancer-stemness","score":0.2043,"url":"https://openalex.org/keywords/cancer-stemness"},{"display_name":"ZEB1","id":"zeb1","score":0.2306,"url":"https://openalex.org/keywords/zeb1"},{"display_name":"CD24","id":"cd24","score":0.2633,"url":"https://openalex.org/keywords/cd24"},{"display_name":"tumor dormancy","id":"tumor-dormancy","score":0.3058,"url":"https://openalex.org/keywords/tumor-dormancy"},{"display_name":"ALDH1","id":"aldh1","score":0.4178,"url":"https://openalex.org/keywords/aldh1"},{"display_name":"cancer stem-like cells","id":"cancer-stem-like-cells","score":0.368,"url":"https://openalex.org/keywords/cancer-stem-like-cells"},{"display_name":"side population cells","id":"side-population","score":0.4081,"url":"https://openalex.org/keywords/side-population"},{"display_name":"disseminated tumor cells","id":"disseminated-tumor-cells","score":0.3295,"url":"https://openalex.org/keywords/disseminated-tumor-cells"},{"display_name":"mesenchymal-epithelial transition","id":"mesenchymal-epithelial-transition","score":0.2697,"url":"https://openalex.org/keywords/mesenchymal-epithelial-transition"},{"display_name":"TWIST1","id":"twist1","score":0.2078,"url":"https://openalex.org/keywords/twist1"},{"display_name":"mammary stem cells","id":"mammary-stem-cells","score":0.3893,"url":"https://openalex.org/keywords/mammary-stem-cells"},{"display_name":"mammosphere formation","id":"mammosphere-formation","score":0.5007,"url":"https://openalex.org/keywords/mammosphere-formation"},{"display_name":"sphere formation","id":"sphere-formation","score":0.4636,"url":"https://openalex.org/keywords/sphere-formation"},{"display_name":"SNAI1","id":"snail1","score":0.2139,"url":"https://openalex.org/keywords/snail1"},{"display_name":"Lgr5","id":"lgr5","score":0.2007,"url":"https://openalex.org/keywords/lgr5"},{"display_name":"tumor plasticity","id":"tumor-plasticity","score":0.2893,"url":"https://openalex.org/keywords/tumor-plasticity"},{"display_name":"tumor sphere formation","id":"tumor-sphere-formation","score":0.3629,"url":"https://openalex.org/keywords/tumor-sphere-formation"},{"display_name":"cancer stem cell markers","id":"cancer-stem-cell-markers","score":0.5069,"url":"https://openalex.org/keywords/cancer-stem-cell-markers"},{"display_name":"tumor spheres","id":"tumor-spheres","score":0.3984,"url":"https://openalex.org/keywords/tumor-spheres"},{"display_name":"spheroid formation","id":"spheroid-formation","score":0.239,"url":"https://openalex.org/keywords/spheroid-formation"},{"display_name":"tumor organoids","id":"tumor-organoids","score":0.2184,"url":"https://openalex.org/keywords/tumor-organoids"},{"display_name":"ALDH1A1","id":"aldh1a1","score":0.2149,"url":"https://openalex.org/keywords/aldh1a1"}],"legacy_keywords":["Cancer Stem Cells","Tumor Metastasis","Epithelial-Mesenchymal Transition","Stem Cell Niches","Tumorigenic Cells","Metastatic Colonization","Microenvironment Regulation","Drug Resistance","Cell Plasticity","Organoid Models"],"openalex_id":"https://openalex.org/T10336","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T10336","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10336","works_count":86711,"label":"Cancer Cells and Metastasis","provider":"openalex","revision":"9c82c2280e86d92c","taxonomy_revision":"f050b5d4780b1289","title":"Cancer Cells and Metastasis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240179350102370","address_version":"morton4x16-v1","coordinates":[4,27,2730,10336],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}