{"cited_by_count":4350324,"description":"This cluster of papers explores the molecular mechanisms, regulation, and implications of apoptosis and other forms of cell death, with a focus on the roles of Bcl-2 family proteins, mitochondria, TNF signaling, caspases, and reactive oxygen species. It also delves into the application of these insights in cancer therapy.","display_name":"Cell death mechanisms and regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10294","wikipedia":"https://en.wikipedia.org/wiki/Apoptosis"},"field_id":"13","id":"T10294","keywords":[{"display_name":"Bcl-2 family proteins","id":"bcl-2-family-proteins","score":0.4883,"url":"https://openalex.org/keywords/bcl-2-family-proteins"},{"display_name":"programmed cell death","id":"programmed-cell-death","score":0.3255,"url":"https://openalex.org/keywords/programmed-cell-death"},{"display_name":"mitochondrial apoptosis","id":"mitochondrial-apoptosis","score":0.2975,"url":"https://openalex.org/keywords/mitochondrial-apoptosis"},{"display_name":"cytochrome c release","id":"cytochrome-c-release","score":0.3739,"url":"https://openalex.org/keywords/cytochrome-c-release"},{"display_name":"caspase-8","id":"caspase-8","score":0.3386,"url":"https://openalex.org/keywords/caspase-8"},{"display_name":"Bcl-xL","id":"bcl-xl","score":0.3058,"url":"https://openalex.org/keywords/bcl-xl"},{"display_name":"caspase-9","id":"caspase-9","score":0.2342,"url":"https://openalex.org/keywords/caspase-9"},{"display_name":"caspase activation","id":"caspase-activation","score":0.2857,"url":"https://openalex.org/keywords/caspase-activation"},{"display_name":"TRAIL","id":"trail","score":0.2944,"url":"https://openalex.org/keywords/trail"},{"display_name":"necroptosis","id":"necroptosis","score":0.335,"url":"https://openalex.org/keywords/necroptosis"},{"display_name":"Fas","id":"fas","score":0.2543,"url":"https://openalex.org/keywords/fas"},{"display_name":"Fas ligand","id":"fas-ligand","score":0.2368,"url":"https://openalex.org/keywords/fas-ligand"},{"display_name":"Mcl-1","id":"mcl-1","score":0.2899,"url":"https://openalex.org/keywords/mcl-1"},{"display_name":"caspases","id":"caspases","score":0.363,"url":"https://openalex.org/keywords/caspases"},{"display_name":"anti-apoptotic proteins","id":"anti-apoptotic-proteins","score":0.4096,"url":"https://openalex.org/keywords/anti-apoptotic-proteins"},{"display_name":"apoptosis resistance","id":"apoptosis-resistance","score":0.2041,"url":"https://openalex.org/keywords/apoptosis-resistance"},{"display_name":"Bak","id":"bak","score":0.5134,"url":"https://openalex.org/keywords/bak"},{"display_name":"apoptosis regulation","id":"apoptosis-regulation","score":0.4264,"url":"https://openalex.org/keywords/apoptosis-regulation"},{"display_name":"inhibitor of apoptosis proteins","id":"inhibitor-of-apoptosis-proteins","score":0.516,"url":"https://openalex.org/keywords/inhibitor-of-apoptosis-proteins"},{"display_name":"death receptor signaling","id":"death-receptor-signaling","score":0.5328,"url":"https://openalex.org/keywords/death-receptor-signaling"},{"display_name":"DR5","id":"dr5","score":0.4615,"url":"https://openalex.org/keywords/dr5"},{"display_name":"TRAIL resistance","id":"trail-resistance","score":0.6355,"url":"https://openalex.org/keywords/trail-resistance"},{"display_name":"XIAP","id":"xiap","score":0.3168,"url":"https://openalex.org/keywords/xiap"},{"display_name":"RIPK3","id":"ripk3","score":0.4262,"url":"https://openalex.org/keywords/ripk3"},{"display_name":"RIPK1","id":"ripk1","score":0.417,"url":"https://openalex.org/keywords/ripk1"}],"legacy_keywords":["Apoptosis","Cell Death","Bcl-2 Family","Mitochondria","TNF Signaling","Caspases","Reactive Oxygen Species","Necroptosis","Programmed Cell Death","Cancer Therapy"],"openalex_id":"https://openalex.org/T10294","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10294","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10294","works_count":113210,"label":"Cell death mechanisms and regulation","provider":"openalex","revision":"7e8fc217075b5dd7","taxonomy_revision":"f050b5d4780b1289","title":"Cell death mechanisms and regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173949746817667","address_version":"morton4x16-v1","coordinates":[1,13,1312,10294],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}