{"cited_by_count":3314413,"description":"This cluster of papers explores the mechanisms, diagnosis, and treatment of neuropathic pain, focusing on central sensitization, neuroinflammation, glial activation, and the modulation of pain perception. It covers topics such as nociception, neuronal plasticity, chronic pain, hyperalgesia, and diabetic neuropathy.","display_name":"Pain Mechanisms and Treatments","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10196","wikipedia":"https://en.wikipedia.org/wiki/Neuropathic_pain"},"field_id":"27","id":"T10196","keywords":[{"display_name":"neuropathic pain","id":"neuropathic-pain","score":0.4223,"url":"https://openalex.org/keywords/neuropathic-pain"},{"display_name":"nociception","id":"nociception","score":0.5242,"url":"https://openalex.org/keywords/nociception"},{"display_name":"dorsal horn","id":"spinal-cord-dorsal-horn","score":0.6241,"url":"https://openalex.org/keywords/spinal-cord-dorsal-horn"},{"display_name":"antinociception","id":"antinociception","score":0.4925,"url":"https://openalex.org/keywords/antinociception"},{"display_name":"dorsal root ganglia","id":"dorsal-root-ganglia","score":0.3204,"url":"https://openalex.org/keywords/dorsal-root-ganglia"},{"display_name":"hyperalgesia","id":"hyperalgesia","score":0.5516,"url":"https://openalex.org/keywords/hyperalgesia"},{"display_name":"mechanical allodynia","id":"mechanical-allodynia","score":0.7544,"url":"https://openalex.org/keywords/mechanical-allodynia"},{"display_name":"central sensitization","id":"central-sensitization","score":0.3735,"url":"https://openalex.org/keywords/central-sensitization"},{"display_name":"inflammatory pain","id":"inflammatory-pain","score":0.6104,"url":"https://openalex.org/keywords/inflammatory-pain"},{"display_name":"pain modulation","id":"pain-modulation","score":0.4326,"url":"https://openalex.org/keywords/pain-modulation"},{"display_name":"nociceptors","id":"nociceptors","score":0.5219,"url":"https://openalex.org/keywords/nociceptors"},{"display_name":"intrathecal administration","id":"intrathecal-administration","score":0.3589,"url":"https://openalex.org/keywords/intrathecal-administration"},{"display_name":"thermal hyperalgesia","id":"thermal-hyperalgesia","score":0.7525,"url":"https://openalex.org/keywords/thermal-hyperalgesia"},{"display_name":"chronic constriction injury","id":"chronic-constriction-injury","score":0.8447,"url":"https://openalex.org/keywords/chronic-constriction-injury"},{"display_name":"allodynia","id":"allodynia","score":0.4947,"url":"https://openalex.org/keywords/allodynia"},{"display_name":"pain mechanisms","id":"pain-mechanisms","score":0.4402,"url":"https://openalex.org/keywords/pain-mechanisms"},{"display_name":"descending pain modulation","id":"descending-pain-modulation","score":0.7156,"url":"https://openalex.org/keywords/descending-pain-modulation"},{"display_name":"diabetic neuropathic pain","id":"painful-diabetic-neuropathy","score":0.7149,"url":"https://openalex.org/keywords/painful-diabetic-neuropathy"},{"display_name":"diabetic peripheral neuropathy","id":"diabetic-peripheral-neuropathy","score":0.2355,"url":"https://openalex.org/keywords/diabetic-peripheral-neuropathy"},{"display_name":"dorsal root ganglion neurons","id":"dorsal-root-ganglion-neurons","score":0.2465,"url":"https://openalex.org/keywords/dorsal-root-ganglion-neurons"},{"display_name":"formalin test","id":"formalin-test","score":0.4593,"url":"https://openalex.org/keywords/formalin-test"},{"display_name":"mechanical hyperalgesia","id":"mechanical-hyperalgesia","score":0.6818,"url":"https://openalex.org/keywords/mechanical-hyperalgesia"},{"display_name":"complete Freund's adjuvant","id":"complete-freund-s-adjuvant","score":0.2973,"url":"https://openalex.org/keywords/complete-freund-s-adjuvant"},{"display_name":"pain threshold","id":"pain-threshold","score":0.2326,"url":"https://openalex.org/keywords/pain-threshold"},{"display_name":"pregabalin","id":"pregabalin","score":0.2,"url":"https://openalex.org/keywords/pregabalin"}],"legacy_keywords":["Neuropathic Pain","Central Sensitization","Nociception","Neuroinflammation","Pain Modulation","Glial Activation","Neuronal Plasticity","Chronic Pain","Hyperalgesia","Diabetic Neuropathy"],"openalex_id":"https://openalex.org/T10196","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2737","url":"/topics/T10196","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10196","works_count":138368,"label":"Pain Mechanisms and Treatments","provider":"openalex","revision":"706b4906b99b5299","taxonomy_revision":"f050b5d4780b1289","title":"Pain Mechanisms and Treatments","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36108824210188582","address_version":"morton4x16-v1","coordinates":[4,27,2737,10196],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}