{"cited_by_count":3908008,"description":"This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.","display_name":"Protein Kinase Regulation and GTPase Signaling","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10169","wikipedia":"https://en.wikipedia.org/wiki/Ras_signaling"},"field_id":"13","id":"T10169","keywords":[{"display_name":"Rho GTPases","id":"rho-gtpases","score":0.3475,"url":"https://openalex.org/keywords/rho-gtpases"},{"display_name":"RhoA","id":"rhoa","score":0.2669,"url":"https://openalex.org/keywords/rhoa"},{"display_name":"Rac1","id":"rac1","score":0.224,"url":"https://openalex.org/keywords/rac1"},{"display_name":"Ras signaling","id":"ras-signaling","score":0.2632,"url":"https://openalex.org/keywords/ras-signaling"},{"display_name":"Cdc42","id":"cdc42","score":0.2773,"url":"https://openalex.org/keywords/cdc42"},{"display_name":"small GTPases","id":"small-gtpases","score":0.2924,"url":"https://openalex.org/keywords/small-gtpases"},{"display_name":"oncogenic Ras","id":"oncogenic-ras","score":0.386,"url":"https://openalex.org/keywords/oncogenic-ras"},{"display_name":"guanine nucleotide exchange factor","id":"guanine-nucleotide-exchange-factor","score":0.3859,"url":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor"},{"display_name":"Ras","id":"ras","score":0.2445,"url":"https://openalex.org/keywords/ras"},{"display_name":"Rho kinase","id":"rho-kinase","score":0.2026,"url":"https://openalex.org/keywords/rho-kinase"},{"display_name":"SH2 domain","id":"sh2-domain","score":0.2716,"url":"https://openalex.org/keywords/sh2-domain"},{"display_name":"SH3 domain","id":"sh3-domain","score":0.2588,"url":"https://openalex.org/keywords/sh3-domain"},{"display_name":"autophosphorylation","id":"autophosphorylation","score":0.2259,"url":"https://openalex.org/keywords/autophosphorylation"},{"display_name":"protein kinase C alpha","id":"protein-kinase-c-alpha","score":0.2108,"url":"https://openalex.org/keywords/protein-kinase-c-alpha"},{"display_name":"GTPase-activating protein","id":"gtpase-activating-protein","score":0.3353,"url":"https://openalex.org/keywords/gtpase-activating-protein"},{"display_name":"PKC isoforms","id":"pkc-isoforms","score":0.4235,"url":"https://openalex.org/keywords/pkc-isoforms"},{"display_name":"Raf-1","id":"raf-1","score":0.2601,"url":"https://openalex.org/keywords/raf-1"},{"display_name":"kinase activation","id":"kinase-activation","score":0.2858,"url":"https://openalex.org/keywords/kinase-activation"},{"display_name":"kinase regulation","id":"kinase-regulation","score":0.2911,"url":"https://openalex.org/keywords/kinase-regulation"},{"display_name":"pleckstrin homology domain","id":"ph-domain","score":0.2952,"url":"https://openalex.org/keywords/ph-domain"},{"display_name":"protein kinase C epsilon","id":"pkc-epsilon","score":0.2061,"url":"https://openalex.org/keywords/pkc-epsilon"},{"display_name":"Ras activation","id":"ras-activation","score":0.4813,"url":"https://openalex.org/keywords/ras-activation"},{"display_name":"Rho GTPase signaling","id":"rho-gtpase-signaling","score":0.2643,"url":"https://openalex.org/keywords/rho-gtpase-signaling"},{"display_name":"H-Ras","id":"h-ras","score":0.3334,"url":"https://openalex.org/keywords/h-ras"},{"display_name":"Grb2","id":"grb2","score":0.2462,"url":"https://openalex.org/keywords/grb2"}],"legacy_keywords":["Ras Signaling","Protein Kinases","GTPases","Cell Regulation","Cancer Therapy","Calcium Signaling","Phospholipase C","Cell Migration","Oncogenic Mutations","Transcriptional Regulation"],"openalex_id":"https://openalex.org/T10169","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10169","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10169","works_count":102438,"label":"Protein Kinase Regulation and GTPase Signaling","provider":"openalex","revision":"e5170d40e5f6f1de","taxonomy_revision":"f050b5d4780b1289","title":"Protein Kinase Regulation and GTPase Signaling","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36042594614551051","address_version":"morton4x16-v1","coordinates":[1,13,1312,10169],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}