{"cited_by_count":1464694,"description":"This cluster of papers explores the advancements and challenges in platinum-based cancer chemotherapy, focusing on the molecular mechanisms of action, resistance, and toxicity associated with platinum drugs. It also delves into the development of new metal complexes as potential therapeutics, DNA interactions of metal compounds, and the exploration of ruthenium compounds as anticancer agents.","display_name":"Metal complexes synthesis and properties","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10163","wikipedia":"https://en.wikipedia.org/wiki/Platinum-based_chemotherapy"},"field_id":"27","id":"T10163","keywords":[{"display_name":"DNA binding","id":"dna-binding","score":0.2521,"url":"https://openalex.org/keywords/dna-binding"},{"display_name":"platinum(II) complexes","id":"platinum-ii-complexes","score":0.3018,"url":"https://openalex.org/keywords/platinum-ii-complexes"},{"display_name":"zinc(II) complexes","id":"zinc-ii-complexes","score":0.2076,"url":"https://openalex.org/keywords/zinc-ii-complexes"},{"display_name":"DNA intercalation","id":"dna-intercalation","score":0.3256,"url":"https://openalex.org/keywords/dna-intercalation"},{"display_name":"platinum complexes","id":"platinum-complexes","score":0.2312,"url":"https://openalex.org/keywords/platinum-complexes"},{"display_name":"platinum anticancer drugs","id":"platinum-based-anticancer-drugs","score":0.7443,"url":"https://openalex.org/keywords/platinum-based-anticancer-drugs"},{"display_name":"DNA cleavage","id":"dna-cleavage","score":0.3032,"url":"https://openalex.org/keywords/dna-cleavage"},{"display_name":"ruthenium(II) complexes","id":"ruthenium-ii-complexes","score":0.2097,"url":"https://openalex.org/keywords/ruthenium-ii-complexes"},{"display_name":"anticancer metal complexes","id":"anticancer-metal-complexes","score":0.8885,"url":"https://openalex.org/keywords/anticancer-metal-complexes"},{"display_name":"metal-based anticancer agents","id":"metal-based-anticancer-agents","score":0.8224,"url":"https://openalex.org/keywords/metal-based-anticancer-agents"},{"display_name":"coordination compound synthesis","id":"coordination-compound-synthesis","score":0.286,"url":"https://openalex.org/keywords/coordination-compound-synthesis"},{"display_name":"calf thymus DNA","id":"calf-thymus-dna","score":0.3286,"url":"https://openalex.org/keywords/calf-thymus-dna"},{"display_name":"octahedral geometry","id":"octahedral-geometry","score":0.3446,"url":"https://openalex.org/keywords/octahedral-geometry"},{"display_name":"metal-based drugs","id":"metal-based-drugs","score":0.5921,"url":"https://openalex.org/keywords/metal-based-drugs"},{"display_name":"platinum(IV) complexes","id":"platinum-iv-complexes","score":0.4151,"url":"https://openalex.org/keywords/platinum-iv-complexes"},{"display_name":"cisplatin comparison","id":"cisplatin-comparison","score":0.615,"url":"https://openalex.org/keywords/cisplatin-comparison"},{"display_name":"Schiff base complexes","id":"schiff-base-metal-complexes","score":0.2965,"url":"https://openalex.org/keywords/schiff-base-metal-complexes"},{"display_name":"gold(III) complexes","id":"gold-iii-complexes","score":0.2781,"url":"https://openalex.org/keywords/gold-iii-complexes"},{"display_name":"ruthenium(III) complexes","id":"ruthenium-iii-complexes","score":0.2866,"url":"https://openalex.org/keywords/ruthenium-iii-complexes"},{"display_name":"bovine serum albumin binding","id":"bovine-serum-albumin-binding","score":0.5396,"url":"https://openalex.org/keywords/bovine-serum-albumin-binding"},{"display_name":"cisplatin analogues","id":"cisplatin-analogues","score":0.7909,"url":"https://openalex.org/keywords/cisplatin-analogues"},{"display_name":"ruthenium polypyridyl complexes","id":"ruthenium-polypyridyl-complexes","score":0.2186,"url":"https://openalex.org/keywords/ruthenium-polypyridyl-complexes"},{"display_name":"DNA interaction","id":"dna-interaction","score":0.3882,"url":"https://openalex.org/keywords/dna-interaction"},{"display_name":"platinum-DNA adducts","id":"platinum-dna-adducts","score":0.693,"url":"https://openalex.org/keywords/platinum-dna-adducts"},{"display_name":"tetrahedral geometry","id":"tetrahedral-geometry","score":0.2133,"url":"https://openalex.org/keywords/tetrahedral-geometry"}],"legacy_keywords":["Platinum-Based Drugs","Cisplatin Resistance","Metal Complexes","Anticancer Agents","Molecular Mechanisms","DNA Interactions","Ruthenium Compounds","Chemical Biology","Drug Development","Cellular Processing"],"openalex_id":"https://openalex.org/T10163","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T10163","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10163","works_count":77778,"label":"Metal complexes synthesis and properties","provider":"openalex","revision":"e13f62d280b8204b","taxonomy_revision":"f050b5d4780b1289","title":"Metal complexes synthesis and properties","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36108824084111850","address_version":"morton4x16-v1","coordinates":[4,27,2730,10163],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}