{"cited_by_count":4184074,"description":"This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.","display_name":"DNA Repair Mechanisms","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10123","wikipedia":"https://en.wikipedia.org/wiki/DNA_damage_response"},"field_id":"13","id":"T10123","keywords":[{"display_name":"DNA repair","id":"dna-repair","score":0.352,"url":"https://openalex.org/keywords/dna-repair"},{"display_name":"DNA damage response","id":"dna-damage-response","score":0.3408,"url":"https://openalex.org/keywords/dna-damage-response"},{"display_name":"homologous recombination","id":"homologous-recombination","score":0.416,"url":"https://openalex.org/keywords/homologous-recombination"},{"display_name":"DNA double-strand break repair","id":"double-strand-break-repair","score":0.5886,"url":"https://openalex.org/keywords/double-strand-break-repair"},{"display_name":"DNA replication","id":"dna-replication","score":0.2607,"url":"https://openalex.org/keywords/dna-replication"},{"display_name":"genome stability","id":"genomic-stability","score":0.376,"url":"https://openalex.org/keywords/genomic-stability"},{"display_name":"DNA double-strand breaks","id":"dna-double-strand-breaks","score":0.35,"url":"https://openalex.org/keywords/dna-double-strand-breaks"},{"display_name":"non-homologous end joining","id":"non-homologous-end-joining","score":0.5206,"url":"https://openalex.org/keywords/non-homologous-end-joining"},{"display_name":"nucleotide excision repair","id":"nucleotide-excision-repair","score":0.6035,"url":"https://openalex.org/keywords/nucleotide-excision-repair"},{"display_name":"base excision repair","id":"base-excision-repair","score":0.5532,"url":"https://openalex.org/keywords/base-excision-repair"},{"display_name":"DNA mismatch repair","id":"dna-mismatch-repair","score":0.3095,"url":"https://openalex.org/keywords/dna-mismatch-repair"},{"display_name":"RAD51","id":"rad51","score":0.5383,"url":"https://openalex.org/keywords/rad51"},{"display_name":"UV-induced DNA damage","id":"uv-induced-dna-damage","score":0.5985,"url":"https://openalex.org/keywords/uv-induced-dna-damage"},{"display_name":"replication stress","id":"replication-stress","score":0.4542,"url":"https://openalex.org/keywords/replication-stress"},{"display_name":"translesion synthesis","id":"translesion-synthesis","score":0.7857,"url":"https://openalex.org/keywords/translesion-synthesis"},{"display_name":"meiotic recombination","id":"meiotic-recombination","score":0.3284,"url":"https://openalex.org/keywords/meiotic-recombination"},{"display_name":"single-stranded DNA","id":"single-stranded-dna","score":0.209,"url":"https://openalex.org/keywords/single-stranded-dna"},{"display_name":"RecA","id":"reca","score":0.461,"url":"https://openalex.org/keywords/reca"},{"display_name":"DNA damage checkpoint","id":"dna-damage-checkpoint","score":0.5703,"url":"https://openalex.org/keywords/dna-damage-checkpoint"},{"display_name":"DNA polymerase","id":"dna-polymerase","score":0.2395,"url":"https://openalex.org/keywords/dna-polymerase"},{"display_name":"DNA glycosylase","id":"dna-glycosylase","score":0.5439,"url":"https://openalex.org/keywords/dna-glycosylase"},{"display_name":"Fanconi anemia","id":"fanconi-anemia","score":0.2981,"url":"https://openalex.org/keywords/fanconi-anemia"},{"display_name":"xeroderma pigmentosum","id":"xeroderma-pigmentosum","score":0.4047,"url":"https://openalex.org/keywords/xeroderma-pigmentosum"},{"display_name":"excision repair","id":"dna-excision-repair","score":0.6802,"url":"https://openalex.org/keywords/dna-excision-repair"},{"display_name":"DNA repair deficiency","id":"dna-repair-deficiency","score":0.2953,"url":"https://openalex.org/keywords/dna-repair-deficiency"}],"legacy_keywords":["DNA Damage","Repair","Genomic Instability","ATM and ATR Kinases","Homologous Recombination","Cell Cycle Checkpoints","Cancer","Histone H2AX","Chromatin","Genome Stability"],"openalex_id":"https://openalex.org/T10123","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10123","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10123","works_count":128634,"label":"DNA Repair Mechanisms","provider":"openalex","revision":"ca3a162dc14a7460","taxonomy_revision":"f050b5d4780b1289","title":"DNA Repair Mechanisms","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36042594605638283","address_version":"morton4x16-v1","coordinates":[1,13,1312,10123],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}