{"cited_by_count":2879275,"description":"This cluster of papers focuses on the pathophysiology of osteoarthritis, with an emphasis on cartilage degradation, inflammation, joint mechanics, and potential therapeutic approaches such as cartilage regeneration using mesenchymal stem cells. It also covers the role of chondrocytes, matrix metalloproteinases, and synovitis in the development and progression of osteoarthritis.","display_name":"Osteoarthritis Treatment and Mechanisms","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10105","wikipedia":"https://en.wikipedia.org/wiki/Osteoarthritis"},"field_id":"27","id":"T10105","keywords":[{"display_name":"osteoarthritis","id":"osteoarthritis","score":0.4153,"url":"https://openalex.org/keywords/osteoarthritis"},{"display_name":"knee osteoarthritis","id":"knee-osteoarthritis","score":0.3909,"url":"https://openalex.org/keywords/knee-osteoarthritis"},{"display_name":"articular cartilage","id":"articular-cartilage","score":0.5763,"url":"https://openalex.org/keywords/articular-cartilage"},{"display_name":"chondrocytes","id":"chondrocytes","score":0.5728,"url":"https://openalex.org/keywords/chondrocytes"},{"display_name":"cartilage degeneration","id":"cartilage-degeneration","score":0.7026,"url":"https://openalex.org/keywords/cartilage-degeneration"},{"display_name":"cartilage repair","id":"cartilage-repair","score":0.6192,"url":"https://openalex.org/keywords/cartilage-repair"},{"display_name":"cartilage regeneration","id":"cartilage-regeneration","score":0.5077,"url":"https://openalex.org/keywords/cartilage-regeneration"},{"display_name":"type II collagen","id":"type-ii-collagen","score":0.4336,"url":"https://openalex.org/keywords/type-ii-collagen"},{"display_name":"intra-articular injection","id":"intra-articular-injection","score":0.4679,"url":"https://openalex.org/keywords/intra-articular-injection"},{"display_name":"chondrogenesis","id":"chondrogenesis","score":0.3967,"url":"https://openalex.org/keywords/chondrogenesis"},{"display_name":"chondrogenic differentiation","id":"chondrogenic-differentiation","score":0.3451,"url":"https://openalex.org/keywords/chondrogenic-differentiation"},{"display_name":"cartilage","id":"cartilage","score":0.3468,"url":"https://openalex.org/keywords/cartilage"},{"display_name":"synovial fluid","id":"synovial-fluid","score":0.2168,"url":"https://openalex.org/keywords/synovial-fluid"},{"display_name":"cartilage defects","id":"cartilage-defects","score":0.5183,"url":"https://openalex.org/keywords/cartilage-defects"},{"display_name":"cartilage tissue engineering","id":"cartilage-tissue-engineering","score":0.3827,"url":"https://openalex.org/keywords/cartilage-tissue-engineering"},{"display_name":"cartilage damage","id":"cartilage-damage","score":0.4728,"url":"https://openalex.org/keywords/cartilage-damage"},{"display_name":"aggrecan","id":"aggrecan","score":0.4503,"url":"https://openalex.org/keywords/aggrecan"},{"display_name":"synovium","id":"synovium","score":0.2064,"url":"https://openalex.org/keywords/synovium"},{"display_name":"articular cartilage degeneration","id":"articular-cartilage-degeneration","score":0.6593,"url":"https://openalex.org/keywords/articular-cartilage-degeneration"},{"display_name":"subchondral bone","id":"subchondral-bone","score":0.5717,"url":"https://openalex.org/keywords/subchondral-bone"},{"display_name":"articular chondrocytes","id":"articular-chondrocytes","score":0.7498,"url":"https://openalex.org/keywords/articular-chondrocytes"},{"display_name":"chondroprotection","id":"chondroprotection","score":0.7332,"url":"https://openalex.org/keywords/chondroprotection"},{"display_name":"MMP-13","id":"mmp-13","score":0.3956,"url":"https://openalex.org/keywords/mmp-13"},{"display_name":"articular cartilage repair","id":"articular-cartilage-repair","score":0.6945,"url":"https://openalex.org/keywords/articular-cartilage-repair"},{"display_name":"Kellgren-Lawrence grade","id":"kellgren-lawrence-grade","score":0.497,"url":"https://openalex.org/keywords/kellgren-lawrence-grade"}],"legacy_keywords":["Osteoarthritis","Cartilage","Chondrocyte","Inflammation","Joint","Regeneration","Matrix Metalloproteinases","Synovitis","Hypertrophy","Mesenchymal Stem Cells"],"openalex_id":"https://openalex.org/T10105","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2745","url":"/topics/T10105","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10105","works_count":162886,"label":"Osteoarthritis Treatment and Mechanisms","provider":"openalex","revision":"0f3c3cf7d74368fc","taxonomy_revision":"f050b5d4780b1289","title":"Osteoarthritis Treatment and Mechanisms","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36108822071140654","address_version":"morton4x16-v1","coordinates":[4,27,2745,10105],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}