{"cited_by_count":3666676,"description":"This cluster of papers focuses on the role of microRNAs in gene expression regulation, particularly in the context of cancer development and progression. It covers topics such as microRNA biogenesis, targeting specificity, biomarker potential, and therapeutic applications in cancer treatment.","display_name":"MicroRNA in disease regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10062","wikipedia":"https://en.wikipedia.org/wiki/MicroRNA"},"field_id":"13","id":"T10062","keywords":[{"display_name":"microRNA","id":"microrna","score":0.3284,"url":"https://openalex.org/keywords/microrna"},{"display_name":"microRNA target regulation","id":"microrna-target-regulation","score":0.6214,"url":"https://openalex.org/keywords/microrna-target-regulation"},{"display_name":"tumor suppressor microRNA","id":"tumor-suppressor-microrna","score":0.8146,"url":"https://openalex.org/keywords/tumor-suppressor-microrna"},{"display_name":"miRNA target genes","id":"microrna-target-genes","score":0.46,"url":"https://openalex.org/keywords/microrna-target-genes"},{"display_name":"microRNA expression","id":"microrna-expression","score":0.3595,"url":"https://openalex.org/keywords/microrna-expression"},{"display_name":"miRNA expression profiling","id":"microrna-expression-profiling","score":0.4928,"url":"https://openalex.org/keywords/microrna-expression-profiling"},{"display_name":"3' untranslated region","id":"3-untranslated-region","score":0.2084,"url":"https://openalex.org/keywords/3-untranslated-region"},{"display_name":"circulating microRNAs","id":"circulating-micrornas","score":0.544,"url":"https://openalex.org/keywords/circulating-micrornas"},{"display_name":"miR-21","id":"mir-21","score":0.4008,"url":"https://openalex.org/keywords/mir-21"},{"display_name":"microRNA regulation","id":"microrna-regulation","score":0.3514,"url":"https://openalex.org/keywords/microrna-regulation"},{"display_name":"microRNA biogenesis","id":"microrna-biogenesis","score":0.5267,"url":"https://openalex.org/keywords/microrna-biogenesis"},{"display_name":"oncogenic microRNA","id":"oncogenic-microrna","score":0.8045,"url":"https://openalex.org/keywords/oncogenic-microrna"},{"display_name":"miRNA-based therapy","id":"microrna-therapy","score":0.5952,"url":"https://openalex.org/keywords/microrna-therapy"},{"display_name":"miR-155","id":"mir-155","score":0.3163,"url":"https://openalex.org/keywords/mir-155"},{"display_name":"miRNA target prediction","id":"mirna-target-prediction","score":0.485,"url":"https://openalex.org/keywords/mirna-target-prediction"},{"display_name":"miR-145","id":"mir-145","score":0.414,"url":"https://openalex.org/keywords/mir-145"},{"display_name":"microRNA biomarkers","id":"microrna-biomarkers","score":0.4528,"url":"https://openalex.org/keywords/microrna-biomarkers"},{"display_name":"microRNA downregulation","id":"microrna-downregulation","score":0.6861,"url":"https://openalex.org/keywords/microrna-downregulation"},{"display_name":"microRNA signature","id":"microrna-signature","score":0.5471,"url":"https://openalex.org/keywords/microrna-signature"},{"display_name":"miR-34a","id":"mir-34a","score":0.4031,"url":"https://openalex.org/keywords/mir-34a"},{"display_name":"differentially expressed miRNAs","id":"differentially-expressed-mirnas","score":0.3617,"url":"https://openalex.org/keywords/differentially-expressed-mirnas"},{"display_name":"miR-146a","id":"mir-146a","score":0.3121,"url":"https://openalex.org/keywords/mir-146a"},{"display_name":"serum microRNA","id":"serum-mirna","score":0.5262,"url":"https://openalex.org/keywords/serum-mirna"},{"display_name":"microRNA dysregulation","id":"mirna-dysregulation","score":0.5209,"url":"https://openalex.org/keywords/mirna-dysregulation"},{"display_name":"microRNA binding sites","id":"microrna-binding-sites","score":0.3863,"url":"https://openalex.org/keywords/microrna-binding-sites"}],"legacy_keywords":["MicroRNA","Gene Expression","Cancer","Regulation","Biomarkers","Biogenesis","Targeting","Therapeutics","Metastasis","Dysregulation"],"openalex_id":"https://openalex.org/T10062","source_created_date":"2024-01-23T15:27:05","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1306","url":"/topics/T10062","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10062","works_count":128081,"label":"MicroRNA in disease regulation","provider":"openalex","revision":"2e4260e141683fa7","taxonomy_revision":"f050b5d4780b1289","title":"MicroRNA in disease regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36042592588458691","address_version":"morton4x16-v1","coordinates":[1,13,1306,10062],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}